34 products were found matching "K04849"!

(S)-(-)-BAY-K-8644 is an activator of voltage-sensitive L-type calcium channels. It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function. When combined with BIX01294 (Cay-13124), (S)-(-)-BAY-K-8644 can enable reprogramming of mouse...

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 µM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in...

Description: (S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) is an agonist of L-type Ca2+ channels, activating Ba2+ currents with an EC50 of 32 nM. Target: Calcium Channel. Smiles: COC(=O)C1=C(C)NC(C)=C([C@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O. References: Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic...

Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.

Ziconotide is a synthetic version of omega-conopeptide MVIIA, a peptide toxin originally found in the venom of the fish-eating marine snail C. magus, that blocks N-type calcium channels in rat brain membranes (Kds = 1.1-18 pM, IC50s = 2-55 pM)., It blocks high-voltage-activated calcium currents in rat superior...

PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg.Formal Name: N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-L-tyrosinamide. CAS Number: 217171-01-2. Molecular Formula:...

Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine (Cay-26080) by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a...

Protein function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The...

Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx...

Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). It also inhibits the protein-protein interaction between CRMP2 and the NMDA receptor NR2B subunit. Tat-CBD3 (10 µM) inhibits the Cav2.2-CRMP2...

Tat-CBD3A6K is a peptide and derivative of the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2) protein-protein interaction inhibitor Tat-CBD3 (Cay-37448). Tat-CBD3A6K (10 mg/kg) prevents decreases in the paw withdrawal threshold in a rat model of antiretroviral...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse CACNa1B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse CACNa1B....