Lorglumide (sodium salt)

Cholecystokinin (CCK) is a peptide hormone that, through specific receptors, induces pancreatic growth and enzyme secretion, smooth muscle contraction in the gall bladder and stomach, and modulates feeding and behavior. Lorglumide is a nonpeptidic antagonist of the CCK A receptor (CCK1, IC50 = 50 nM) that is 60-fold less effective at the CCK B receptor (CCK2, IC50 = 3 µM). It blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion. Lorglumide is commonly used to study the roles of CCK1 in tissues and in animals.Formal Name: 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxo-pentanoic acid, monosodium salt. CAS Number: 1021868-76-7. Molecular Formula: C22H31Cl2N2O4 . Na. Formula Weight: 481.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. SMILES: ClC1=C(Cl)C=CC(C(NC(C(N(CCCCC)CCCCC)=O)CCC([O-])=O)=O)=C1.[Na]. InChi Code: InChI=1S/C22H32Cl2N2O4.Na/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16,/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28),/p-1. InChi Key: IEGKIAKFIRAEMH-UHFFFAOYSA-M.