61 products were found matching "K04194"!

Recombinant CHO-K1 cells stably overexpress human cholecystokinin A receptor (CCKA) on the surface and contain high levels of G protein Galphaq and Galphas to couple with the receptor in downstream signaling pathways.

Protein function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system....

A specific cholecystokinin receptor antagonist. It inhibits the effects of cholecystokinin on pancreatic growth and the development of pancreatic lesions and chemically induced carcinogenesis of the pancreas in rats.

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholecystokinin A receptor Protein function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a...

Cholecystokinin (CCK) is a peptide hormone that, through specific receptors, induces pancreatic growth and enzyme secretion, smooth muscle contraction in the gall bladder and stomach, and modulates feeding and behavior. Lorglumide is a nonpeptidic antagonist of the CCK A receptor (CCK1, IC50 = 50 nM) that is 60-fold...

Loxiglumide is a cholecystokinin (CCK) receptor antagonist that inhibits CCK-8 binding to central and peripheral CCK receptors with Ki values of 9.1 and 0.33 µM, respectively. It inhibits CCK-8-induced release of acetylcholine from isolated guinea pig gallbladder (IC50 = 10 nM). Loxiglumide (50 µM) reduces the...

SR 27897 is a nonpeptide cholecystokinin (CCK) receptor antagonist. It selectively binds to CCK1 receptors in rat pancreatic membranes (IC50 = 0.58 nM) over CCK2 receptors in guinea pig cortical membranes and gastrin receptors in guinea pig gastric gland suspensions (IC50s = 489 and 2,883 nM, respectively). SR 27897...

A specific cholecystokinin receptor antagonist. It inhibits the effects of cholecystokinin on pancreatic growth and the development of pancreatic lesions and chemically induced carcinogenesis of the pancreas in rats.

Dexloxiglumide is a cholecystokinin (CCK) receptor antagonist and is the single (R) isomer of loxiglumide (Cay-25534). It selectively binds to the CCK1 receptor over CCK2 in CHO cells expressing the rat receptors (Kis = 0.0234 and 5.88 µM, respectively). Dexloxiglumide (20 µmol/kg) inhibits guinea pig gallbladder...

Devazepide is a nonpeptide antagonist of the cholecystokinin 1 (CCK1) receptor (Ki = 0.3 nM). It is selective for CCK1 over the CCK2 receptor (Ki = 342 nM). Devazepide inhibits CCK-8-induced amylase release in isolated dispersed rat pancreatic acini (IC50 = 25.4 nM). It reduces CCK-8-induced decreases in gastric...