Deruxtecan
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A reactive drug-linker molecule containing Dxd, has been linked trastuzumab as an ADC to target... more
Product information "Deruxtecan"
A reactive drug-linker molecule containing Dxd, has been linked trastuzumab as an ADC to target Dxd to tumor cells, binds to HER2 in a cell-free assay, is cytotoxic to breast cancer cells in vitro, and induces tumor regression in a BT474 breast cancer mouse xenograft model. when linked to trastuzumab. Formulation: A solid. InChI: InChI=1S/C52H56FN9O13/c1-3-52(73)33-19-38-48-31(24-62(38)50(71)32(33)25-75-51(52)72)47-35(14-13-30-28(2)34(53)20-36(60-48)46(30)47)58-43(67)26-74-27-57-41(65)22-56-49(70)37(18-29-10-6-4-7-11-29)59-42(66)23-55-40(64)21-54-39(63)12-8-5-9-17-61-44(68)15-16-45(61)69/h4,6-7,10-11,15-16,19-20,35,37,73H,3,5,8-9,12-14,17-18,21-27H2,1-2H3,(H,54,63)(H,55,64)(H,56,70)(H,57,65)(H,58,67)(H,59,66)/t35-,37-,52-/m0/s1. InChIKey: WXNSCLIZKHLNSG-MCZRLCSDSA-N. SMILES: O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
| Keywords: | Maleimidocaproyl-Gly-Gly-Phe-Gly-Dxd, Mc-GGFG-Dxd, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7 |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43189 |
Properties
| Application: | Reactive drug-linker molecule, ADC |
| Conjugate: | No |
| MW: | 1034.07 D |
| Formula: | C52H56FN9O13 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 1599440-13-7| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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