DAMGO (trifluoroacetate salt)

DAMGO is a selective peptide agonist of the µ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human µ-, delta-, and kappa-opioid receptors, respectively). DAMGO displays higher efficacy than morphine (Cay-ISO60147) for µ-opioid-induced nociception in rats.Formal Name: L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-L-phenylalaninamide, 2,2,2-trifluoroacetate. Synonyms: [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin, DAGO, NIH 10891, RX-783006. Molecular Formula: C26H35N5O6 . XCF3COOH. Formula Weight: 513.6. Purity: >98%. Formulation: (Request formulation change), A clear film. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C26H35N5O6.C2HF3O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18,3-2(4,5)1(6)7/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36),(H,6,7)/t17-,21+,22+,/m1./s1. InChi Key: NIGIQPUQVVEMTD-NJUGUJQKSA-N.