Cyclosporin H

Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 µM. Unlike cyclosporin A (Cay-12088), cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation in vitro.Formal Name: 5-(N-methyl-D-valine)-cyclosporin A. CAS Number: 83602-39-5. Synonyms: 5-(N-methyl-D-valine)-Cyclosporin A, Sandoz 37-839. Molecular Formula: C62H111N11O12. Formula Weight: 1202.6. Purity: >95%. Formulation: (Request formulation change), A white powder. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O[C@@H]([C@](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)CC)=O)([H])N(C([C@@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)[C@H](C)C/C=C/C. InChi Code: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(3. InChi Key: PMATZTZNYRCHOR-JLPRAAIDSA-N.