AS-2863619

AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively). It induces Foxp3 expression in isolated mouse naïve T cells when used at a concentration of 1 µM alone or synergistically in combination with TGF-beta. AS-2863619 (30 mg/kg) decreases ear edema and induces production of Foxp3+ regulatory T cells (Tregs) in mice. It also reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name: 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine, dihydrochloride. CAS Number: 2241300-51-4. Molecular Formula: C16H12N8O . 2HCl. Formula Weight: 405.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: NC1=NON=C1C2=NC(C=NC=C3)=C3N2C4=CC=C(N=C(C)N5)C5=C4.Cl.Cl. InChi Code: InChI=1S/C16H12N8O.2ClH/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14,,/h2-7H,1H3,(H2,17,23)(H,19,20),2*1H. InChi Key: LHUAALWRORLTCJ-UHFFFAOYSA-N.