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AS-2863619
AS-2863619

Item number: Cay30976-1

AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively). It induces Foxp3 expression in isolated mouse naïve T cells when used at a concentration of 1 µM alone or synergistically in combination with TGF-beta. AS-2863619 (30 mg/kg) decreases ear edema and...
Keywords: 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine, dihydrochloride
Application: Cdk8 / Cdk19 dual inhibitor
CAS 2241300-51-4
MW: 405.2 D
From 102.00€ *
Review
AS2863619
AS2863619

Item number: TGM-T8378-100mg

Description: AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively). Target: CDK, STAT. Smiles: Cl.Cl.Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N. References: Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into...
Application: Cdk8 / Cdk19 dual inhibitor
CAS 2241300-51-4
MW: 405.24 D
From 125.00€ *
Review