Amylin (8-37) (human) (trifluoroacetate salt)

Amylin (8-37) is a peptide fragment of amylin (Cay-24274, Cay-24275). It inhibits osteoblast proliferation, but not bone resorption, induced by full-length human amylin and does not act as an agonist at amylin receptors. Amylin (8-37) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures. It is cytotoxic to RINm5F islet beta-cells in vitro when used at a concentration of 25 µM, an effect that is inversely correlated with mature fibril content.Formal Name: L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosine, trifluoroacetate salt. Synonyms: IAPP (8-37) (human), Islet Amyloid Polypeptide (8-37) (human). Molecular Formula: C138H215N41O46 . XCF3COOH. Formula Weight: 3184.4. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C138H215N41O46.C2HF3O2/c1-19-65(12)106(133(220)166-80(40-61(4)5)117(204)170-93(56-182)129(216)173-95(58-184)130(217)179-108(70(17)186)135(222)168-89(50-101(145)194)124(211)174-104(63(8)9)131(218)151-53-103(196)155-91(54-180)126(213)165-88(49-100(144)193)125(212)178-109(71(18)187)136(223)169-90(137(224)225)44-74-32-34-76(188)35-33-74)176-112(199)67(14)153-102(195)52-150-113(200)82(42-72-27-22-20-23-28-72)161-121(208)86(47-98(142)191)163-122(209)87(48-99(143)192)164-127(214)92(55-181)172-128(215)94(57-183)171-119(206)84(45-75-51-148-59-152-75)167-132(219)105(64(10)11)175-123(210)81(41-62(6)7)160-118(205)83(43-73-29-24-21-25-30-73)162-120(207)85(46-97(141)190)158-111(198)68(15)154-116(203)79(39-60(2)3)159-114(201)77(31-26-38-149-138(146)147)156-115(202)78(36-37-96(140)189)157-134(221)107(69(16)185)177-110(197)66(13)139,3-2(4,5)1(6)7/h20-25,27-30,32-35,51,59-71,77-95,104-109,180-188H,19,26,31,36-50,52-58,139H2,1-18H3,(H2,140,189)(H2,141,190)(H2,142,191)(H2,143,192)(H2,144,193)(H2,145,194)(H,148,152)(H,150,200)(H,151,218)(H,153,195)(H,154,203)(H,155,196)(H,156,202)(H,157,221)(H,158,198)(H,159,201)(H,160,205)(H,161,208)(H,162,207)(H,163,209)(H,164,214)(H,165,213)(H,166,220)(H,167,219)(H,168,222)(H,169,223)(H,170,204)(H,171,206)(H,172,215)(H,173,216)(H,174,211)(H,175,210)(H,176,199)(H,177,197)(H,178,212)(H,179,217)(H,224,225)(H4,146,147,149),(H,6,7)/t65-,66-,67-,68-,69+,70+,71+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,104-,105-,106-,107-,108-,109-,/m0./s1. InChi Key: LEJOSZKCTLTERK-OJNSZWJJSA-N.