A71915 (trifluoroacetate salt)

A GC-A antagonist (Ki = 0.66 nM), inhibits cGMP production induced by ANP in NB-OK-1 cells (pA2 = 9.48), induces dilation and increases glomerular blood flow in rat hydronephrotic renal vascular segments but inhibits ANP-induced dilation in the same preparations at 1 µM, prevents BNP-induced increases in spontaneous action potential frequency in isolated mouse sinoatrial node myocytes at 0.5 µM. Formulation: A solid. InChI: InChI=1S/C69H116N26O15S2.C2HF3O2/c1-5-36(3)53-64(109)90-46(30-52(98)99)61(106)87-44(23-15-27-83-69(78)79)60(105)94-54(37(4)6-2)65(110)95-33-40-19-11-10-18-39(40)29-49(95)63(108)88-43(22-14-26-82-68(76)77)58(103)91-47(55(71)100)34-111-112-35-48(92-56(101)41(70)20-12-24-80-66(72)73)62(107)89-45(28-38-16-8-7-9-17-38)57(102)85-31-50(96)84-32-51(97)86-42(59(104)93-53)21-13-25-81-67(74)75,3-2(4,5)1(6)7/h10-11,18-19,36-38,41-49,53-54H,5-9,12-17,20-35,70H2,1-4H3,(H2,71,100)(H,84,96)(H,85,102)(H,86,97)(H,87,106)(H,88,108)(H,89,107)(H,90,109)(H,91,103)(H,92,101)(H,93,104)(H,94,105)(H,98,99)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)(H4,78,79,83),(H,6,7)/t36-,37-,41-,42-,43-,44-,45-,46-,47-,48-,49+,53-,54-,/m0./s1. InChIKey: MVTYOEJNLDZOOR-FVZXGZEGSA-N. SMILES: O=C1N2[C@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@]1([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)CC(O)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)=O)CC3CCCCC3)=O)NC([C@@H](N)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)([H])CC4=CC=CC=C4C2.OC(C(F)(F)F)=O