Blocking Peptides

Peptide (NRIIERLNRVPAPPDV) corresponding to amino acids 701 to 716 of human IKKe/IKK-i (1,2). Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and in?ammatory responses. NF-kB mediates the expression of a great variety of...

Peptide (CQYQAPDMDTLQIHVME) corresponding to amino acids 400 to 416 of human IKKg (1,2), which are identical to those of mouse homologue (2). Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and in?ammatory responses. NF-kB...

Peptide corresponding to aa525-540 of human IL-1RAcP, which is identical to those of mouse and rat origins , The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with...

Peptide corresponding to amino acids 549 to 569 of human IL-1RAcP, which differs from the sequence of mouse origin by three amino acids (1)., The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP)...

A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and...

A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1). The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates...

A novel cytokine was recently identified in human and mouse and designated IL-21 (1), which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with...

Synthetic peptide (DSLFRGLALTVQWES) corresponding to amino acids 560 to 574 of human IL-22R precursor. Blocking peptide for I8443-10 (polyclonal rabbit anti-human Interleukin 22R, CT antibody). , Storage and Stability:, May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store...

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified (1-3). The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family (3,4). IL-22R forms a complex with IL-10 receptor b chain...

Peptide corresponding to amino acid 546 to 564 of human IRAK2 (1). , , The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor 1 (IL-1R1) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which...

Peptide corresponding to amino acids 571 to 590 of human IRAK2 (2)., , The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB (1),...

Peptide (CSSKFSWDEYEQYKKE) corresponding to amino acids 581 to 596 of human IRAK-M (3). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-kB by...