Peptides

Description: Ipamorelin (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Target: Others. Smiles: C([C@@H](NC([C@H](CC1=CN=CN1)NC(C(C)(C)N)=O)=O)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N)=O)=O)=O)C3=CC4=C(C=C3)C=CC=C4. References: Raun K , Hansen B , Johansen N , et al....

Description: Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction. Smiles:...

Description: Copper tripeptide (GHK-Cu) is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine, with a strong affinity for copper(II). First isolated from human plasma, it is also found in saliva and urine. Target: Endogenous Metabolite, Others. Smiles:...

Description: Adipotide as a prototype in a new class of candidate drugs that may be useful for treating obesity in humans. Target: Others. References: Barnhart K F , Christianson D R , Hanley P W , et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.[J]....

Tat (47-57) is an arginine-rich cell-penetrating peptide (CPP) and a synthetic fragment of HIV-1 Tat. It has been used to deliver different types of cargo to cells, including fluorescent proteins and small molecules. InChI:...

GR83074 is a peptide antagonist of the neurokinin-2 (NK2) receptor. It selectively inhibits neurokinin A-induced contractions in rat colon muscularis mucosae, which express NK2 receptors, over substance P-induced contractions in guinea pig ileum longitudinal smooth muscle strips, which express NK1 receptors (pKbs =...

Human T cell leukemia virus type 1 (HTLV-1) Tax (11-19) is an immunogenic T cell epitope derived from the HTLV-1 oncoprotein Tax. It binds to HLA-A*0201 in a cell-free assay when used at a concentration of 1 nM. Co-culture of HTLV-1 Tax (11-19)-primed isolated human HLA-A2-positive mature dendritic cells with naïve...

Human cytomegalovirus (CMV) pp65 (495-503) is an immunogenic T cell epitope derived from the CMV matrix protein 65 kDa phosphoprotein (pp65). It binds to HLA-A*0201 in a cell-free assay (IC50 = 90 nM) and induces activation of patient-derived antigen-specific CD8+ T cells. Human CMV pp65 (495-503) has been used as...

[pS345]-Chk1 (340-349) is a peptide fragment of the serine/threonine kinase checkpoint kinase 1 (Chk1) that is phosphorylated at the serine in position 345 (Ser345). Phosphorylation at Ser345 and Ser317 is involved in activation of Chk1, which results in cell cycle arrest at the S or G2/M phase. InChI:...

[D-Asp3]-Microcystin-LR is a cyanotoxin that has been found in Anabaena and an activator of nuclear factor erythroid 2-related factor 2 (Nrf2). It induces Nrf2 activation in HepG2 cells when used at concentrations ranging from 0.3-3 µM. InChI:...

TET 830-modified T helper cell epitope from tetanus toxin is an immunogenic T helper (Th) cell epitope derived from the tetanus toxin helper peptide. It increases serum levels of IgG, IgA, IL-4, and IFN-gamma in combination with self-amplifying RNA lipid nanoparticles (saLNPs) in a mouse model of severe acute...

des-(7-13) Semaglutide is a derivative of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide (Cay-40231, Cay-29969, Cay-40170) that does not contain amino acids 7-13, which correspond to amino acids 13-19 in GLP-1 and includes two residues important for GLP-1R interaction. InChI:...