HTLV-1 Tax (11-19) (trifluoroacetate salt)

Human T cell leukemia virus type 1 (HTLV-1) Tax (11-19) is an immunogenic T cell epitope derived from the HTLV-1 oncoprotein Tax. It binds to HLA-A*0201 in a cell-free assay when used at a concentration of 1 nM. Co-culture of HTLV-1 Tax (11-19)-primed isolated human HLA-A2-positive mature dendritic cells with naïve autologous peripheral blood lymphocytes induces IFN-gamma production in the CD8+ T cell population. HTLV-1 Tax (11-19) has been used to evaluate the role of dendritic cells in the cytotoxic CD8+ T cell response in transgenic mice. InChI: InChI=1S/C56H79N9O12.C2HF3O2/c1-31(2)25-40(57)49(69)60-41(26-32(3)4)51(71)61-42(27-35-13-10-9-11-14-35)50(70)58-30-46(68)59-44(29-37-18-22-39(67)23-19-37)55(75)65-24-12-15-45(65)53(73)63-47(33(5)6)54(74)62-43(28-36-16-20-38(66)21-17-36)52(72)64-48(34(7)8)56(76)77,3-2(4,5)1(6)7/h9-11,13-14,16-23,31-34,40-45,47-48,66-67H,12,15,24-30,57H2,1-8H3,(H,58,70)(H,59,68)(H,60,69)(H,61,71)(H,62,74)(H,63,73)(H,64,72)(H,76,77),(H,6,7)/t40-,41-,42-,43-,44-,45-,47-,48-,/m0./s1 InChIKey: BCXCIHWSNSVXNF-LYDKTYGCSA-N SMILES: O=C(N(CCC1)[C@@H]1C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)CC(C=C2)=CC=C2O)=O)=O)[C@@H](NC(CNC([C@@H](NC([C@H](CC(C)C)NC([C@@H](N)CC(C)C)=O)=O)CC3=CC=CC=C3)=O)=O)CC(C=C4)=CC=C4O.OC(C(F)(F)F)=O