Peptides

Description: N'-Nitro-D-arginine (N'-Nitro-D-arginine) is a Building Block. Target: NO Synthase, Others. Smiles: N[C@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O. References: Pudupakkam S, Harris KA, Jamieson WG, DeRose G, Scott JA, Carson MW, Schlag MG, Kvietys PR, Potter RF. Ischemic tolerance in skeletal muscle: role of...

Description: Icotrokinra is an orally bioavailable and highly selective antagonist of the interleukin-23 receptor (IL-23R), thereby interfering with IL-23-mediated signaling cascades. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 value of 5.6 pM, and it...

Substance P (7-11) is a peptide fragment of substance P (Cay-24035). It is formed from substance P via hydrolysis by neutral endopeptidase. Substance P (7-11) (>1 µM) increases collagenase and prostaglandin E2 (PGE2, Cay-14041) production in isolated bovine articular chondrocytes. It increases intracellular calcium...

FITC-Stearyl-R8 is a fluorescently labeled form of the stearic acid-conjugated cell-penetrating peptide stearyl-R8. FITC displays excitation/emission maxima of 485/535 nm, respectively. FITC-Stearyl-R8 has been used as a positive control to monitor cellular uptake of cell-penetrating peptidomimetics. Formal Name:...

IFN-alpha receptor recognition peptide 1 (IRRP1) is a peptide that corresponds to amino acids 52-58 of full-length IFN-alpha and is a positive modulator of IFN-alpha/beta receptor 1 (IFNAR). It increases the binding capacity of Daudi cells for IFN-alpha2. IRRP1 (1 µg/ml) enhances the antiproliferative effect of...

IGF-2 (33-40) is a peptide fragment of insulin-like growth factor 2 (IGF-2). It has been used in the development of antibodies against IGF-2. Formal Name: (L-seryl-L-arginyl-L-valyl-L-seryl-L-arginyl-L-arginyl-L-seryl-L-arginine), trifluoroacetate salt. Synonyms: H-Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg-OH Insulin-like...

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is an RGD-containing integrin-blocking peptide. It inhibits integrin alpha5beta1 and integrin alphaVbeta3 (IC50s = 200 and 20 nM, respectively). GRGDSP (1 nM) induces chemotaxis of primary human foreskin fibroblasts (HFFs). It reduces angiogenesis induced by basic FGF (bFGF) in a...

Citrullinated [Cys369]-collagen type II (R360) (358-369)-biotin peptide is a biotinylated derivative of a mono-citrullinated peptide corresponding to a sequence found in the fibril-forming heterotrimeric protein collagen type II, which undergoes citrullination by peptidyl arginine deiminase 2 (PAD2) and PAD4. It...

Oxytocin-d10 is intended for use as an internal standard for the quantification of oxytocin (Cay-11799) by GC- or LC-MS. Oxytocin is a nine-amino acid peptide hormone with roles in development, parturition, lactation, olfaction, and social behavior. It is synthesized in hypothalamic magnocellular neurons and in some...

(DYKDDDDK)3 is a peptide containing three tandem repeats of the epitope tag DYKDDDDK that has been used to elute DYKDDDDK-tagged proteins during affinity purification. Molecular Formula: C123H176N30O58  XCF3COOH. Formula Weight: 3002.9. Purity: >95%. Formulation (Request formulation change): A solid. Peptide...

Biotin-Rab-22A (1-10) is a biotinylated version of the GTPase Ras-related protein Rab-22A that corresponds to residues 1-10 of human and mouse Rab-22A. It inhibits RhoA-GTP increases induced by Rab-22A (1-38) or an oncogenic Rab-22A fusion protein Rab-22A-NeoF1 in 143B whole cell lysates. Formal Name:...

Salinamide A is a bicyclic depsipeptide bacterial metabolite originally isolated from C. xamachana that has antibacterial and anti-inflammatory activities. It is an inhibitor of E. coli RNA polymerase (IC50 = 0. µM). Salinamide A is active against the Gram-positive bacteria S. pneumoniae and S. pyogenes (MICs = 4...