Transforming Growth Factor ß-1/TGFß1/TGFB1 Protein (recombinant mouse)

Activity: Measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is less than 1 ng/ml. Protein Construction: Recombinant Mouse Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed. Sequence: Ala279-Ser390. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 14 kDa. Protein function: Transforming growth factor beta 1 (TGFß1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-ß1, TGF-ß2 and TGF-ß3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-ß receptor type II (TßR-II), and a TGF-ß receptor type I (TßR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-ß expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. Protein function: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. [The UniProt Consortium]