Transforming Growth Factor beta 1

Transforming Growth Factor beta 1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
009-001-W26-0005 5 µg - -

6 - 10 business days*

204.00€
 
Transforming Growth Factor beta 1 purity was determined to be greater than 98% as determined by... more
Product information "Transforming Growth Factor beta 1"
Transforming Growth Factor beta 1 purity was determined to be greater than 98% as determined by reducing and non-reducing SDS-pAGE. Protein function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. [The UniProt Consortium]
Keywords: TGFB, TGFB1
Supplier: Rockland Immunochemicals
Supplier-Nr: 009-001-W26-0005

Properties

Application: Cell culture
Conjugate: No
Host: E.coli
Species reactivity: human

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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