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Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). (www.uniprot.org) Produced in E.coli. Single, non-glycosylated polypeptide chain containing 227 amino acids. The ED50 as determined by the dose-dependant stimulation of Human TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 5 x 105 IU/mg.
Keywords: | OSM, MGC20461 |
Supplier: | Biomol GmbH |
Supplier-Nr: | 51571.1 |
Properties
Application: | Cell culture |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Human |
MW: | 26000 D |
Purity: | >98% |
Database Information
KEGG ID : | K05418 | Find alternatives |
UniProt ID : | P13725 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Our products are for laboratory research use only: Not for administration to humans!