IL-1alpha (human) (rec.) (His)

IL-1alpha (human) (rec.) (His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HR-20001A-C010 10 µg - -

3 - 9 business days*

187.00€
CHI-HR-20001A-C050 50 µg - -

3 - 9 business days*

528.00€
 
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta.... more
Product information "IL-1alpha (human) (rec.) (His)"
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Keywords: IL1A, IL1F1, IL-1 alpha, Hematopoietin-1, Interleukin-1 alpha, Interleukin-1alpha, IL-1F1, IL-1A
Supplier: Chimerigen Laboratories
Supplier-Nr: HR-20001A

Properties

Application: Bioassays
Conjugate: No
Expressed in: E.coli
Origin: Human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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