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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG70100.20 | 20 µg | - | - |
6 - 14 business days* |
336.00€
|
||
ARG70100.100 | 100 µg | - | - |
6 - 14 business days* |
840.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Growth factor involved in bone and cartilage formation. During cartilage... more
Product information "Human GDF5 recombinant protein (Active)"
Protein function: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. [The UniProt Consortium]
Keywords: | Gdf5, GDF-5, Bmp14, BMP-14, Bone morphogenetic protein 14, Growth/differentiation factor 5 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG70100 |
Properties
Application: | SDS-PAGE, Cell culture |
Conjugate: | No |
Species reactivity: | human |
Format: | Purified |
Database Information
KEGG ID : | K04664 | Matching products |
UniProt ID : | P43027 | Matching products |
Gene ID | GeneID 14563 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
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