BMP-2, human recombinant (rHuBMP-2) (His)

BMP-2, human recombinant (rHuBMP-2) (His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HR-200BMP2-C010 10 µg - -

3 - 9 business days*

209.00€
CHI-HR-200BMP2-C050 50 µg - -

3 - 9 business days*

600.00€
 
The extracellular domain of human BMP-2 (aa 289-396) is fused at the C-terminus to a His-tag.... more
Product information "BMP-2, human recombinant (rHuBMP-2) (His)"
The extracellular domain of human BMP-2 (aa 289-396) is fused at the C-terminus to a His-tag. Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
Keywords: BMP2, Bone Morphogenetic Protein 2
Supplier: Chimerigen Laboratories
Supplier-Nr: HR-200BMP2

Properties

Application: Bioassays
Conjugate: No
Host: E.coli
Species reactivity: human
Purity: >95%
Format: Lyophilized

Database Information

KEGG ID : K21283 | Matching products
UniProt ID : P12643 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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