Trimetazidine-d8 (hydrochloride)

Trimetazidine-d8 is intended for use as an internal standard for the quantification of trimetazidine by GC- or LC-MS. Trimetazidine is a cardioprotective agent. It decreases ischemia-reperfusion injury-induced pyroptosis in H9c2 rat cardiomyocytes when used at concentrations ranging from 5 to 100 µM. In vivo, trimetazidine (10 mg/kg) reduces cardiac TNF-alpha and cardiac troponin I (CTnI) levels, improves left ventricular ejection fraction, and increases survival in a rat model of ventricular fibrillation-induced post-resuscitation myocardial dysfunction. Trimetazidine (20 mg/kg) increases overall survival, prevents neuromuscular junction degeneration, and delays motor function decline in an SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS). Formulations containing trimetazidine have been used in the treatment of angina.Formal Name: 1-(2,3,4-trimethoxybenzyl)piperazine-2,2,3,3,5,5,6,6-d8, dihydrochloride. CAS Number: 1219795-37-5. Molecular Formula: C14H14D8N2O3 . 2HCl. Formula Weight: 347.3. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble, Water: Slightly soluble. SMILES: [2H]C1(C([2H])(NC([2H])(C([2H])(N1CC2=C(OC)C(OC)=C(OC)C=C2)[2H])[2H])[2H])[2H].Cl.Cl. InChi Code: InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16,,/h4-5,15H,6-10H2,1-3H3,2*1H/i6D2,7D2,8D2,9D2,,. InChi Key: VYFLPFGUVGMBEP-IKGFOUCPSA-N.