Pravadoline

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase. Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 µM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice). In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 µM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone. Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.Formal Name: (4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone. CAS Number: 92623-83-1. Molecular Formula: C23H26N2O3. Formula Weight: 378.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.15 mg/ml. lambdamax: 219, 272, 322 nm. SMILES: CC1=C(C(C2=CC=C(OC)C=C2)=O)C3=C(N1CCN4CCOCC4)C=CC=C3. InChi Code: InChI=1S/C23H26N2O3/c1-17-22(23(26)18-7-9-19(27-2)10-8-18)20-5-3-4-6-21(20)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3. InChi Key: MEUQWHZOUDZXHH-UHFFFAOYSA-N.