MPP+ Iodide

MPP+ is an active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson's disease, including the MPTP model, have been detailed.Formal Name: 1-methyl-4-phenyl-pyridinium, monoiodide. CAS Number: 36913-39-0. Synonyms: N-Methyl-4-Phenylpyridinium Iodide. Molecular Formula: C12H12N . I. Formula Weight: 297.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: C[N+](C=C1)=CC=C1C2=CC=CC=C2.[I-]. InChi Code: InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11,/h2-10H,1H3,1H/q+1,/p-1. InChi Key: RFDFRDXIIKROAI-UHFFFAOYSA-M.