C16 dihydro Ceramide-d9 (d18:0/16:0-d9)

C16 dihydro Ceramide-d9 (d18:0/16:0-d9) is intended for use as an internal standard for the quantification of C16 dihydro ceramide (Cay-24369) by GC- or LC-MS. C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Cay-10681) that lacks the 4,5-trans double bond. C16 dihydro Ceramide (46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome c oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome c release, or channel formation in phospholipid membranes in the absence of C16 ceramide.Formal Name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-hexadecanamide-13,13,14,14,15,15,16,16,16-d9. CAS Number: 2260669-52-9. Synonyms: Cer(d18:0/16:0-d9), Ceramide (d18:0/16:0-d9), N-hexadecanoyl-D-erythro-Dihydrosphingosine-d9, N-Palmitoyl Sphinganine-d9. Molecular Formula: C34H60D9NO3. Formula Weight: 549.0. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: O=C(CCCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC. InChi Code: InChI=1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1/i2D3,4D2,6D2,8D2. InChi Key: GCGTXOVNNFGTPQ-PDMRHGGWSA-N.