Acetazolamide-d3

Acetazolamide-d3 is intended for use as an internal standard for the quantification of acetazolamide by GC- or LC-MS. Acetazolamide is an inhibitor of carbonic anhydrase I (CAI), CAII, CAIX, and CAXII (Kis = 310, 12, 25, and 5.7 nM, respectively, for the human enzymes). It inhibits the migration and invasion of Caki-1, Caki-2, and ACHN renal carcinoma cells when used at a concentration of 10 µM. Acetazolamide (5.6 mg/kg per day) increases currents in calcium-activated potassium channels in patch clamp assays using skeletal muscle tissues isolated from potassium-deficient rats. It induces vasodilation and increases cerebral, renal, and hepatic blood flow and blood oxygen levels in normotensive rabbits when administered at a dose of 12 mg/kg. Formulations containing acetazolamide have been used in the treatment of edema, open-angle glaucoma, epilepsy, and acute mountain sickness.Formal Name: N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-acetamide-2,2,2-d3. CAS Number: 1189904-01-5. Molecular Formula: C4H3D3N4O3S2. Formula Weight: 225.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: NS(C1=NN=C(NC(C([2H])([2H])[2H])=O)S1)(=O)=O. InChi Code: InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)/i1D3. InChi Key: BZKPWHYZMXOIDC-FIBGUPNXSA-N.