(±)12(13)-DiHOME-d4

(±)12(13)-DiHOME-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009994-25 25 µg -

3 - 10 business days*

94.00€
Cay10009994-50 50 µg -

3 - 10 business days*

179.00€
Cay10009994-100 100 µg -

3 - 10 business days*

338.00€
Cay10009994-250 250 µg -

3 - 10 business days*

750.00€
 
(±)12(13)-DiHOME (Cay-10009832) is the diol resulting from the soluble epoxide hydrolase opening... more
Product information "(±)12(13)-DiHOME-d4"
(±)12(13)-DiHOME (Cay-10009832) is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Cay-52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells. However, in renal cortical mitochondria, the conversion of the epoxide to (±)12(13)-DiHOME appears to be part of the detoxification pathway that prevents mitochondrial dysfunction. This diol and the 9,10 isomer can be glucuronidated by human liver and intestinal microsomes as well as recombinant UGT2B7 through a hydroxyl group. High levels of LA-diol glucuronides have been found in the urine of humans with peroxisomal diseases. A mixture of the diols stimulates breast cancer cell proliferation in vitro and disrupts reproductive function in rats at relatively low concentrations.
Keywords: Isoleukotoxin diol-d4, (±)12,13-dihydroxy-9Z-octadecenoic-9,10,12,13-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 10009994-25

Properties

Application: Bioactive lipid assays
MW: 318.5 D
Formula: C18H30D4O4
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, EUH066
P Phrases: P210, P240, P241, P242, P243, P261, P264, P271, P280, P312, P303+P361+P353, P304+P340, P305+P351+P338, P337+P313, P370+P378, P405, P403+P233, P403+P235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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