Tricin

Tricin is a flavone that has been found in O. sativa and has diverse biological activities. It scavenges ABTS (Cay-27317) radicals in a cell-free assay (IC50 = 0.312 mg/ml). Tricin (0.1-10 µM) reduces virus titer and expression of the human cytomegalovirus (HCMV) genes IE1 and UL54 in HCMV-infected human embryonic lung fibroblast (HEL) cells, an effect that can be reversed by overexpression of chemokine (C-C motif) ligand 2 (CCL2). It inhibits IgE-induced degranulation of RBL-2H3 cells (IC50 = 4.83 µM). In vivo, tricin (37.5 mg/kg per day) reduces tumor growth and the number of lung metastases in a CT26 murine colon carcinoma model.Formal Name: 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-32-1. Synonyms: NSC 294579, 4',5,7-Trihydroxy-3',5'-dimethoxyflavone. Molecular Formula: C17H14O7. Formula Weight: 330.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 50 mg/ml, DMSO: 10 mg/ml. lambdamax: 246, 271, 354 nm. SMILES: O=C1C=C(C2=CC(OC)=C(O)C(OC)=C2)OC3=C1C(O)=CC(O)=C3. InChi Code: InChI=1S/C17H14O7/c1-22-14-3-8(4-15(23-2)17(14)21)12-7-11(20)16-10(19)5-9(18)6-13(16)24-12/h3-7,18-19,21H,1-2H3. InChi Key: HRGUSFBJBOKSML-UHFFFAOYSA-N. Origin: Synthetic.