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Tomatine is a steroidal saponin that has been found in S. lycopersicum and has diverse biological activities. It is active against a panel of 19 plant pathogenic fungi (EC50s = 13-912 µM) and inhibits the growth of L. amazonensis promastigotes (IC50 = 124 nM). Tomatine (0.75, 1, and 1.5 µM) inhibits autophagy and induces apoptosis in SKOV3 ovarian cancer cells. Dietary administration of tomatine (0.1 and 0.2% w/w) decreases serum LDL levels and increases fecal cholesterol secretion in hamsters.Formal Name: (3beta,5alpha,22beta,25S)-spirosolan-3-yl O-beta-D-glucopyranosyl-(1->2)-O-[beta-D-xylopyranosyl-(1->3)]-O-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranoside. CAS Number: 17406-45-0. Synonyms: Lycopersicin, NSC 9223, NSC 234440, alpha-Tomatine. Molecular Formula: C50H83NO21. Formula Weight: 1034.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 2 mg/ml. SMILES: C[C@H]1CC[C@@]2(O[C@]3(C[C@]4([C@@]5(CC[C@]6(C[C@H](CC[C@@]6([C@]5(CC[C@@]4([C@]3([C@@H]2C)[H])C)[H])C)O[C@@]7(O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@]8([C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@]9([C@@H]([C@H]([C@@H](CO9)O)O)O)[H])O[C@@]%10(O[C@@H]([C@H]([. InChi Code: InChI=1S/C50H83NO21/c1-20-7-12-50(51-15-20)21(2)32-28(72-50)14-26-24-6-5-22-13-23(8-10-48(22,3)25(24)9-11-49(26,32)4)65-45-40(63)37(60)41(31(18-54)68-45)69-47-43(71-46-39(62)36(59)34(57)29(16-52)66-46)42(35(58)30(17-53)67-47)70-44-38(61)33(56)27(55)1. InChi Key: REJLGAUYTKNVJM-SGXCCWNXSA-N. Origin: Plant/Tomato.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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