tetranor-PGJM

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis. tetranor-PGJM is a potential PGD2 metabolite, formed by the elimination of the C-9 hydroxyl group. This compound may serve as a useful control in the analysis of PGD2 biosynthesis.Formal Name: 8-((1R,2S)-2-(2-carboxyethyl)-5-oxocyclopent-3-en-1-yl)-6-oxooctanoic acid. CAS Number: 1352751-83-7. Synonyms: tetranor-PGJ Metabolite. Molecular Formula: C16H22O6. Formula Weight: 310.3. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 219 nm. SMILES: O=C1C=C[C@H](CCC(O)=O)[C@H]1CCC(CCCCC(O)=O)=O. InChi Code: InChI=1S/C16H22O6/c17-12(3-1-2-4-15(19)20)7-8-13-11(5-9-14(13)18)6-10-16(21)22/h5,9,11,13H,1-4,6-8,10H2,(H,19,20)(H,21,22)/t11-,13-/m1/s1. InChi Key: KPFBKANRLYZJQP-DGCLKSJQSA-N.