tetranor-PGDM lactone

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis. tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.Formal Name: 8-((4aR,5R,7aS)-2,6-dioxooctahydrocyclopenta[b]pyran-5-yl)-6-oxooctanoic acid. Synonyms: tetranor-Prostaglandin D Metabolite lactone. Molecular Formula: C16H22O6. Formula Weight: 310.3. Purity: >90%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C(CCCCC(O)=O)CC[C@H]1C(C[C@H]2[C@@H]1CCC(O2)=O)=O. InChi Code: InChI=1S/C16H22O6/c17-10(3-1-2-4-15(19)20)5-6-11-12-7-8-16(21)22-14(12)9-13(11)18/h11-12,14H,1-9H2,(H,19,20)/t11-,12-,14+/m1/s1. InChi Key: KRZCZJUXOKTLEH-BZPMIXESSA-N.