tetranor-PGDM-d6

tetranor-PGDM-d6 contains six deuterium atoms at the 17, 17', 18, 18', 19 and 19' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM by GC- or LC-mass spectrometry (MS). Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin PGD-synthase also known as beta-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and murine urine. The levels of tetranor-PGDM and 2,3-dinor-11b-PGF2alpha, a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in mouse urine at a level of 8.1 ± 1.3 ng/mg creatinine.Formal Name: 9alpha-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid-17,17,18,18,19,19-d6. CAS Number: 1314905-92-4. Synonyms: tetranor-Prostaglandin D Metabolite-d6. Molecular Formula: C16H18O7D6. Formula Weight: 334.4. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: Not stable, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H](C1)[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)C1=O. InChi Code: InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-12,14,19H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,14+/m1/s1/i1D2,2D2,4D2. InChi Key: VNJBSPJILLFAIC-OSZDNXCMSA-N.