Termitomycamide B

Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 µg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.Formal Name: N-[2-(1H-indol-2-yl)-2-oxoethyl]-9Z,12Z-octadecadienamide. CAS Number: 1254277-89-8. Molecular Formula: C28H40N2O2. Formula Weight: 436.6. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml. lambdamax: 206, 240, 297 nm. SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(NCC(C1=CC2=C(C=CC=C2)N1)=O)=O. InChi Code: InChI=1S/C28H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-21-28(32)29-23-27(31)26-22-24-19-17-18-20-25(24)30-26/h6-7,9-10,17-20,22,30H,2-5,8,11-16,21,23H2,1H3,(H,29,32)/b7-6-,10-9-. InChi Key: KDZGHQVBEWMXHZ-HZJYTTRNSA-N.