SKF 86002

SKF 86002 is an anti-inflammatory agent. It inhibits rat seminal vesicle prostaglandin H2 (PGH2) synthase (IC50 = 120 µM), as well as prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes (IC50s = 70 and 1 µM, respectively). SKF 86002 inhibits leukotriene B4 (LTB4) and LTC4 production induced by A23187 (Cay-11016) in human neutrophils and monocytes, respectively (IC50 = 20 µM for both). It also inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM). SKF 86002 (10, 30, and 90 mg/kg) reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis. It also decreases serum levels of TNF-alpha and increases survival in a mouse model of LPS and galactosamine-induced endotoxic shock when administered at a dose of 100 mg/kg.Formal Name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-imidazo[2,1-b]thiazole. CAS Number: 72873-74-6. Molecular Formula: C16H12FN3S. Formula Weight: 297.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 238 nm. SMILES: FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1. InChi Code: InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2. InChi Key: YOELZIQOLWZLQC-UHFFFAOYSA-N.