Saponarin

Saponarin is a flavonoid glycoside that has been found in H. vulgare and has diverse biological activities. It prevents UV- or Fenton's reagent-induced lipid peroxidation in cell-free assays. Saponarin (50 and 100 µM) increases intracellular calcium concentrations and induces AMPK phosphorylation in HepG2 and TE 671 cells, as well as increases glucose uptake and reduces glucose production in HepG2 cells. It inhibits the LPS-induced production of TNF-alpha and IL-1beta in RAW 264.7 cells and induces the expression of skin barrier genes encoding hyaluronan synthase-3, aquaporin-3, and the antimicrobial peptide LL-37 in HaCaT cells. In vivo, saponarin (80 mg/kg, p.o) reduces cocaine-induced production of thiobarbituric acid reactive substances (TBARS), decreases in hepatic levels of catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX), and hepatotoxicity in rats.Formal Name: 6-beta-D-glucopyranosyl-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 20310-89-8. Synonyms: Isovitexin 7-glucoside, Petrocomoside. Molecular Formula: C27H30O15. Formula Weight: 594.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 272, 334 nm. SMILES: OC1=C2C(OC(C3=CC=C(C=C3)O)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1[C@]5([H])O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO. InChi Code: InChI=1S/C27H30O15/c28-7-15-19(32)22(35)24(37)26(40-15)18-14(41-27-25(38)23(36)20(33)16(8-29)42-27)6-13-17(21(18)34)11(31)5-12(39-13)9-1-3-10(30)4-2-9/h1-6,15-16,19-20,22-30,32-38H,7-8H2/t15-,16-,19-,20-,22+,23+,24-,25-,26+,27-/m1/s1. InChi Key: HGUVPEBGCAVWID-KETMJRJWSA-N. Origin: Plant/Vaccaria segetalis seed.