Salvigenin

Salvigenin is a polyphenol flavonoid originally found in Alnus japonica with diverse biological activities. It inhibits hydrogen peroxide-induced apoptosis and reduces the generation of reactive oxygen species (ROS) in SH-SY5Y human neuroblastoma cells when used at a concentration of 25 µM. Salvigenin (25 and 50 µM) decreases cleaved caspase-3 levels and the Bax/B cell lymphoma 2 (Bcl-2) ratio in SH-SY5Y cells. It reduces the viability of MCF-7 human breast cancer cells in a concentration-dependent manner. Salvigenin (3.65-9.68 µg/mouse per day) enhances the delayed-type hypersensitivity (DTH) response to sheep red blood cells in mice. It increases the production of IFN-gamma induced by lysate antigens in isolated mouse splenocytes. Salvigenin (9.68 µg/mouse per day) reduces tumor growth in a spontaneous mouse mammary tumor (SMMT) model.Formal Name: 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 19103-54-9. Synonyms: 5-hydroxy-4',6,7-Trimethoxyflavone, 7-O-Methylpectolinarigenin, Psathyrotin. Molecular Formula: C18H16O6. Formula Weight: 328.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. SMILES: O=C1C=C(C2=CC=C(C=C2)OC)OC3=CC(OC)=C(C(O)=C13)OC. InChi Code: InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)13-8-12(19)16-14(24-13)9-15(22-2)18(23-3)17(16)20/h4-9,20H,1-3H3. InChi Key: QCDYOIZVELGOLZ-UHFFFAOYSA-N. Origin: Plant/Salvia japonica.