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Product information "S-Geranylgeranyl-L-glutathione"
S-Geranylgeranyl-L-glutathione is a ligand of the orphan G protein-coupled receptor (GPCR) P2RY8. It selectively induces internalization of P2RY8 over sphingosine-1-phosphate receptor 2 (S1P2), GPR55, cysteinyl leukotriene receptor 1 (CysLT1 receptor), and CysLT2 receptor at 100 nM. S-Geranylgeranyl-L-glutathione (10 nM) inhibits the migration of P2RY8-expressing WEHI-231 B cell lymphoma cells and isolated human tonsil germinal center B cells induced by chemokine (C-X-C motif) ligand 12 (WEHI-231).Formal Name: N5-((R)-1-((carboxymethyl)amino)-1-oxo-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propan-2-yl)-L-glutamine. CAS Number: 2364639-42-7. Synonyms: GGG. Molecular Formula: C30H49N3O6S. Formula Weight: 579.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml (warmed, vortexed). SMILES: OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)=O. InChi Code: InChI=1S/C30H49N3O6S/c1-21(2)9-6-10-22(3)11-7-12-23(4)13-8-14-24(5)17-18-40-20-26(29(37)32-19-28(35)36)33-27(34)16-15-25(31)30(38)39/h9,11,13,17,25-26H,6-8,10,12,14-16,18-20,31H2,1-5H3,(H,32,37)(H,33,34)(H,35,36)(H,38,39)/b22-11+,23-13+,24-17+/t25-,26-/m0/s1. InChi Key: BAJIBEVLRWVBAZ-DPRMOSMCSA-N.
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