Resolvin E2

Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) via an 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils. RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Cay-21175). Hepatic RvE2 levels are increased in mice fed normal chow, as well as in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD), by dietary supplementation with EPA. Plasma levels of RvE2 are increased by dietary supplementation with fish oil containing omega-3 polyunsaturated fatty acids (PUFAs) in patients with peripheral artery disease or chronic kidney disease.Formal Name: 5S,18R-dihydroxy-6E,8Z,11Z,14Z,16E-eicosapentaenoic acid. CAS Number: 865532-70-3. Synonyms: RvE2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 1 mg/ml. lambdamax: 237 nm. SMILES: CC[C@@H](O)/C=C/C=C\C/C=C\C/C=C\C=C\[C@@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H30O4/c1-2-18(21)14-11-9-7-5-3-4-6-8-10-12-15-19(22)16-13-17-20(23)24/h3-4,7-12,14-15,18-19,21-22H,2,5-6,13,16-17H2,1H3,(H,23,24)/b4-3-,9-7-,10-8-,14-11+,15-12+/t18-,19-/m1/s1. InChi Key: KPRHYAOSTOHNQA-NNQKPOSRSA-N.