PtdIns-(3,4,5)-P3-fluorescein (triethylammonium salt)

The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates an intricate signaling cascade that has been implicated in cancer. PtdIns-(3,4,5)-P3 fluorescein is a fluorescent probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.Formal Name: 1-(1-octadecanoyl-fluorescein-2R-octanoylphosphatidyl)inositol-3,4,5-trisphosphate, heptatriethylammonium salt. Synonyms: DOPI-3,4,5-P3-fluorescein, Phosphatidylinositol-3,4,5-triphosphate C-8-fluorescein, PI(3,4,5)P3-fluorescein, PIP3[3',4',5']-fluorescein. Molecular Formula: C46H54NO28P4 . 7C6H16N. Formula Weight: 1908.2. Purity: >90%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: O=C1C=CC2=C(C3=C(C(O)=O)C=C(C(NCCCCCCCC(OC[C@@H](OC(CCCCCCC)=O)COP([O-])(O[C@@H]4[C@H](O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]4O)=O)=O)=O)C=C3)C(C=CC(O)=C5)=C5OC2=C1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC. InChi Code: InChI=1S/C46H61NO28P4.7C6H15N/c1-2-3-4-6-10-13-37(51)70-29(25-69-79(66,67)75-41-39(52)42(72-76(57,58)59)44(74-78(63,64)65)43(40(41)53)73-77(60,61)62)24-68-36(50)12-9-7-5-8-11-20-47-45(54)26-14-17-30(33(21-26)46(55)56)38-31-18-15-27(48)22-34(31)71-35-23-28(49)16-19-32(35)38,7*1-4-7(5-2)6-3/h14-19,21-23,29,39-44,48,52-53H,2-13,20,24-25H2,1H3,(H,47,54)(H,55,56)(H,66,67)(H2,57,58,59)(H2,60,61,62)(H2,63,64,65),7*4-6H2,1-3H3/t29-,39+,40+,41-,42+,43-,44-,,,,,,,/m1......./s1. InChi Key: CZNXJRILJYPMCT-LKBISYOHSA-N.