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Product information "Prostaglandin F2alpha Ethanolamide"
Prostaglandin F2alpha ethanolamide (PGF2alpha-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF2alpha-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2alpha-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.Formal Name: 9alpha,11alpha,15S-trihydroxy-N-(2-hydroxyethyl)-prosta-5Z,13E-dien-1-amide. CAS Number: 353787-70-9. Synonyms: Dinoprost Ethanolamide, PGF2alpha-EA. Molecular Formula: C22H39NO5. Formula Weight: 397.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: Miscible, DMSO: 10 mg/ml, Ethanol: Miscible, PBS (pH 7.2): 10 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(NCCO)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C22H39NO5/c1-2-3-6-9-17(25)12-13-19-18(20(26)16-21(19)27)10-7-4-5-8-11-22(28)23-14-15-24/h4,7,12-13,17-21,24-27H,2-3,5-6,8-11,14-16H2,1H3,(H,23,28)/b7-4-,13-12+/t17-,18+,19+,20-,21+/m0/s1. InChi Key: XCVCLIRZZCGEMU-WLOFLUCMSA-N.
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