Picotamide

Picotamide is an antiplatelet drug that inhibits both thromboxane A2 (TXA2) receptors (Kd = 325 nM) and TXA2 synthase. It significantly inhibits basal and lipopolysaccharide-stimulated TXA2 synthesis by rat peritoneal macrophages when used at 0.5 mM. Formulations containing picotamide have potential applications in the reduction of peripheral artery disease in patients with diabetes.Formal Name: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide. CAS Number: 32828-81-2. Molecular Formula: C21H20N4O3. Formula Weight: 376.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 212 nm. SMILES: O=C(C1=CC=C(OC)C(C(NCC2=CC=CN=C2)=O)=C1)NCC3=CN=CC=C3. InChi Code: InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27). InChi Key: KYWCWBXGRWWINE-UHFFFAOYSA-N.