Oleic Acid (sodium salt)

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). Oleic acid (60 µM) induces release of intracellular calcium in human platelets. In vivo, oleic acid increases TNF-alpha, IL-8, IL-6, and IL-1beta production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).Formal Name: 9Z-octadecenoic acid, monosodium salt. CAS Number: 143-19-1. Synonyms: C18:1(9Z), FA 18:1, 9Z-Octadecenoic Acid, cis-9-Octadecenoic Acid, Sodium Oleate. Molecular Formula: C18H33O2 . Na. Formula Weight: 304.4. Purity: >80%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 1 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 202 nm. SMILES: CCCCCCCC/C=C\CCCCCCCC([O-])=O.[Na+]. InChi Code: InChI=1S/C18H34O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20,/h9-10H,2-8,11-17H2,1H3,(H,19,20),/q,+1/p-1/b10-9-,. InChi Key: BCKXLBQYZLBQEK-KVVVOXFISA-M. Side Chain Carbon Sum: 18:1.