N-Docosahexaenoyl Dopamine

N-Docosahexaenoyl dopamine (DHA-DA) is an amine conjugate of the neurotransmitter dopamine and the polyunsaturated fatty acid docosahexaenoic acid (DHA, Cay-90310). DHA-DA is actively transported into the brain following intraperitoneal injections in mice, resulting in reduced general locomotor activity of 35-40% at a dose of 5 mg/kg. It is theorized that the DHA portion of the molecule serves as a carrier for DA through the blood-brain barrier via a DHA-mediated transport system. DHA-DA exhibits immune-modulating, anti-inflammatory activity in the range of 0.1-2.5 µM, suppressing the production of nitric oxide, IL-6, CCL20, MCP-1, and PGE2 (Cay-14010) in LPS-stimulated macrophages and microglial cells without affecting NF-kappaB activity.Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenamide. CAS Number: 129024-87-9. Synonyms: DHA-DA, NMI 8739. Molecular Formula: C30H41NO3. Formula Weight: 463.7. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: miscible, DMSO: miscible, Ethanol: miscible, Ethanol:PBS(pH 7.2) (1:1): .1 mg/ml colloidal suspension. lambdamax: 282 nm. SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CC=C(O)C(O)=C1)=O. InChi Code: InChI=1S/C30H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-30(34)31-25-24-27-22-23-28(32)29(33)26-27/h3-4,6-7,9-10,12-13,15-16,18-19,22-23,26,32-33H,2,5,8,11,14,17,20-21,24-25H2,1H3,(H,31,34)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-. InChi Key: HXJMZRVSTICUKC-KUBAVDMBSA-N.