Misoprostol (free acid)-d5

Misoprostol (free acid)-d5 is intended for use as an internal standard for the quantification of misoprostol (free acid) (Cay-13821) by GC- or LC-MS. Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.Formal Name: 9-oxo-11alpha,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid. CAS Number: 1337917-44-8. Molecular Formula: C21H31D5O5. Formula Weight: 373.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS pH 7.2: 1 mg/ml. SMILES: CCCC([2H])([2H])C(O)(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)C([2H])([2H])[2H]. InChi Code: InChI=1S/C21H36O5/c1-3-4-13-21(2,26)14-9-11-17-16(18(22)15-19(17)23)10-7-5-6-8-12-20(24)25/h9,11,16-17,19,23,26H,3-8,10,12-15H2,1-2H3,(H,24,25)/b11-9+/t16-,17-,19-,21?/m1/s1/i2D3,13D2. InChi Key: CNWGPXZGIIOYDL-CTASGXJISA-N.