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MEDICA 16 is a G protein-coupled receptor 40 (GPR40) agonist and GPR120 partial agonist. MEDICA 16 induces intracellular calcium mobilization in cells expressing GPR40 or GPR120 in a concentration-dependent manner. It induces ERK activation in cells expressing GPR40 or GPR120 when used at a concentration of 100 µM. MEDICA 16 also inhibits ATP citrate lyase (Kis = 40 and 200 µM for the oxidized and reduced enzyme, respectively). Chronic dietary administration of MEDICA 16 (0.25% w/w) decreases liver acetyl-CoA carboxylase (ACC) and AMP-activated protein kinase (AMPK) levels in a model of insulin resistance using JCR:LA-cp rats, which lack functioning leptin receptors. MEDICA 16 (0.25% w/w in the diet) reduces plasma insulin levels, decreases fasting plasma triacylglycerol levels, and delays the onset of hyperinsulinemia in JCR:LA-cp rats.Formal Name: 3,3,14,14-tetramethylhexadecanedioic acid. CAS Number: 87272-20-6. Synonyms: FA 20:0,O2. Molecular Formula: C20H38O4. Formula Weight: 342.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid), DMF: >100 mg/ml (from Oleic Acid), DMSO: >100 mg/ml (from Oleic Acid), Ethanol: >100 mg/ml (from Oleic Acid), PBS pH 7.2: <100 µg/ml (from Oleic Acid). SMILES: OC(=O)CC(C)(C)CCCCCCCCCCC(C)(C)CC(=O)O. InChi Code: InChI=1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24). InChi Key: HYSMCRNFENOHJH-UHFFFAOYSA-N.
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