Madecassic Acid

Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2, Cay-14010), TNF-alpha, IL-1beta, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 µg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ, Cay-13104). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.Formal Name: (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid. CAS Number: 18449-41-7. Synonyms: Brahmic Acid, NSC 88135. Molecular Formula: C30H48O6. Formula Weight: 504.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMF:PBS (pH 7.2) (1:9): 0.1 mg/mL, DMSO: 5 mg/mL, Ethanol: 3 mg/mL. SMILES: OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5. InChi Code: InChI=1S/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30?/m1/s1. InChi Key: PRAUVHZJPXOEIF-QUKJEOBDSA-N. Origin: Plant/Centella asiatica.