JJH260

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA (Cay-17037) with an IC50 value of 0.57 µM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP, IC50 = 8.5 µM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.Formal Name: 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester. CAS Number: 1831135-30-8. Molecular Formula: C29H34ClN5O5. Formula Weight: 568.1. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml. lambdamax: 220, 301 nm. SMILES: CN(C)C(C=C1)=CC=C1C(N2CCN(C(N(OC(N3CCC(CCC4=CC=C(Cl)C=C4)CC3)=O)C5=O)=O)C5C2)=O. InChi Code: InChI=1S/C29H34ClN5O5/c1-31(2)24-11-7-22(8-12-24)26(36)33-17-18-34-25(19-33)27(37)35(28(34)38)40-29(39)32-15-13-21(14-16-32)4-3-20-5-9-23(30)10-6-20/h5-12,21,25H,3-4,13-19H2,1-2H3. InChi Key: RISSJZZMOJQTIN-UHFFFAOYSA-N.