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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally... more
Product information "Hecogenin"
Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids. It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotective properties. Hecogenin (10 µM) decreases superoxide anion formation induced by N-Formyl-Met-Leu-Phe (fMLP, Cay-21495) in rat neutrophils by 23.6%. It also inhibits myeloperoxidase (MPO) release from human neutrophils activated by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) when used at a concentration of 1 µg/ml. Hecogenin inhibits proliferation of the breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-10A, MCF-7, T47D, BT474, and SK-BR-3 (IC50s = 28.7-38.2 µM). It decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% when used at a concentration of 1 µM. In vivo, hecogenin (15 mg/kg) decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice. It also decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 10 mg/kg three times per week.Formal Name: (3beta,5alpha,25R)-3-hydroxy-spirostan-12-one. CAS Number: 467-55-0. Synonyms: (+)-Hecogenin, NSC 115921. Molecular Formula: C27H42O4. Formula Weight: 430.6. Purity: >80%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 238 nm. SMILES: O=C1[C@@]2(C)[C@](C[C@@]3([H])[C@]2([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O3)([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])C1. InChi Code: InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)12-21-19-6-5-17-11-18(28)8-9-25(17,3)20(19)13-23(29)26(21,24)4/h15-22,24,28H,5-14H2,1-4H3/t15-,16+,17+,18+,19-,20+,21+,22+,24+,25+,26-,27-/m1/s1. InChi Key: QOLRLLFJMZLYQJ-LOBDNJQFSA-N.
Keywords: | (+)-Hecogenin, NSC 115921, (3beta,5alpha,25R)-3-hydroxy-spirostan-12-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 21372 |
Properties
Application: | Spirostan |
MW: | 430.6 D |
Formula: | C27H42O4 |
Purity: | >80% |
Database Information
CAS : | 467-55-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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