DLin-MC3-DMA

DLin-MC3-DMA is an ionizable cationic amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Administration of Factor VII siRNA in DLin-MC3-DMA-containing LNPs reduces plasma Factor VII protein levels in mice. Formulations containing DLin-MC3-DMA have been used in the development of LNPs for siRNA delivery in patients with hereditary transthyretin-mediated amyloidosis.Formal Name: 4-(dimethylamino)-butanoic acid, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester. CAS Number: 1224606-06-7. Synonyms: MC3. Molecular Formula: C43H79NO2. Formula Weight: 642.1. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Soluble, Ethanol: 100 mg/ml. lambdamax: 204 nm. SMILES: CCCCC\C=C/C\C=C/CCCCCCCCC(CCCCCCCC\C=C/C\C=C/CCCCC)OC(=O)CCCN(C)C. InChi Code: InChI=1S/C43H79NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-42(46-43(45)40-37-41-44(3)4)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,42H,5-12,17-18,23-41H2,1-4H3/b15-13-,16-14-,21-19-,22-20-. InChi Key: NRLNQCOGCKAESA-KWXKLSQISA-N.