Deoxycholic Acid (sodium salt hydrate)

Deoxycholic acid (DCA) is a secondary bile acid that is formed via microbial transformation of cholic acid (Cay-20250) in the colon. It can be conjugated to glycine or taurine (Cay-27031) to produce glycodeoxycholic acid (GDCA, Cay-20274) or taurodeoxycholic acid (TDCA, Cay-15935), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA, Cay-16215) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 µM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.Formal Name: 5beta-3alpha,12alpha-dihydroxy-cholan-24-oic acid, monosodium salt, monohydrate. CAS Number: 145224-92-6. Synonyms: DCA, Sodium Deoxycholate. Molecular Formula: C24H39O4 . Na [H2O]. Formula Weight: 432.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC([O-])=O)([H])C1.[Na+].O. InChi Code: InChI=1S/C24H40O4.Na.H2O/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3,,/h14-21,25-26H,4-13H2,1-3H3,(H,27,28),,1H2/q,+1,/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-,,/m1../s1. InChi Key: NDVHNZISGVSFMP-WTCAICSISA-M.