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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31009-1 | 1 mg | - |
6 - 10 business days* |
545.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Delta4-Dafachronic acid-d3 is intended for use as an internal standard for the quantification of... more
Product information "Delta4-Dafachronic Acid-d3"
Delta4-Dafachronic acid-d3 is intended for use as an internal standard for the quantification of Delta4-dafachronic acid (Cay-14100) by GC- or LC-MS. Delta4-Dafachronic acid is a racemic mixture of the sterol-derived hormones (25R)-Delta4-dafachronic acid and (25S)-Delta4-dafachronic acid, ligands of C. elegans nuclear hormone receptor family member DAF-12, a nucleoreceptor involved in dauer diapause, reproductive development, fat metabolism, and lifespan. Delta4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol (Cay-9003100) in C. elegans. It induces transactivation of DAF-12 in NIH3T3 cells expressing the C. elegans or D. immitis receptor (EC50s = 81 and 0.65 nM, respectively). Delta4-Dafachronic acid induces molting of infective D. immitis (heartworm) third-stage larvae into L4 larvae, which is the first stage of the parasitic life cycle in dogs. It also induces the escape trajectory in embryos of the annual killifish A. limnaeus at 25°C, a condition that favors entrance into diapause, when used at a concentration of 75 µM.Formal Name: 3-oxo-cholest-4-en-26-oic-27,27,27-d3 acid. Synonyms: 3-keto-4-Cholestenoic Acid-d3, Delta4-DA-d3. Molecular Formula: C27H39D3O3. Formula Weight: 417.6. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 12.5 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.09 mg/ml. lambdamax: 241 nm. SMILES: O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCCC(C([2H])([2H])[2H])C(O)=O)C)=C1. InChi Code: InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h16-18,21-24H,5-15H2,1-4H3,(H,29,30)/t17-,18?,21+,22-,23+,24+,26+,27-/m1/s1/i2D3. InChi Key: PSXQJZDFWDKBIP-UMHCWJCBSA-N.
Keywords: | 3-keto-4-Cholestenoic Acid-d3, Delta4-DA-d3, 3-oxo-cholest-4-en-26-oic-27,27,27-d3 acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31009 |
Properties
Application: | GC-MS, LC-MS internal standard, quantification, DAF-12 ligand |
MW: | 417.6 D |
Formula: | C27H39D3O3 |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Solid |
Database Information
KEGG ID : | K08701 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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